Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Moderately Good
Based on 32 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Read More
9
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
Read More
8
We investigated the potential of vitamin B12 as a treatment for rheumatoid arthritis, particularly focusing on its ability to target an enzyme called peptidylarginine deiminase isoform 4 (PADI-4). PADI-4 plays a crucial role in a process called citrullination, which is often disrupted in autoimmune conditions like rheumatoid arthritis.
Our findings revealed that vitamin B12 effectively inhibits PADI-4, showing a preference for this enzyme over another similar one, PADI-2. This inhibition corresponds to a decrease in overall cellular citrullination, including the citrullination of histone H3, which is also mediated by PADI-4.
Additionally, we observed that hydroxocobalamin, a special form of vitamin B12, significantly reduced the severity of collagen type II antibody-induced arthritis in mice. It also lowered the expression of key inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL-17A, TNFα, and IL-6.
These promising results suggest that vitamin B12 might be an effective therapeutic avenue for managing rheumatoid arthritis, warranting further investigation in future studies.
Our findings revealed that vitamin B12 effectively inhibits PADI-4, showing a preference for this enzyme over another similar one, PADI-2. This inhibition corresponds to a decrease in overall cellular citrullination, including the citrullination of histone H3, which is also mediated by PADI-4.
Additionally, we observed that hydroxocobalamin, a special form of vitamin B12, significantly reduced the severity of collagen type II antibody-induced arthritis in mice. It also lowered the expression of key inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL-17A, TNFα, and IL-6.
These promising results suggest that vitamin B12 might be an effective therapeutic avenue for managing rheumatoid arthritis, warranting further investigation in future studies.
Read More
Most Useful Reviews
9
Muscle relaxation benefits
21 people found this helpful
For nerve and muscle relaxation, this easily digestible form works excellently. I have been drinking it for over a year, experiencing reduced body aches and irritability. B12 helps relax muscle fibres, relieving tensions. My nails improved too; white spots indicated a lack of B12. I would have avoided many issues had I started this sooner; it truly impacts the nervous system positively.
Read More
9
Supports brain function
17 people found this helpful
As a vegan, I take this in monthly courses. It alleviates muscle and nervous tensions and enhances brain function. A deficiency in Vitamin B12 can lead to neurological disorders, even depression, especially in those over 40. I wholeheartedly recommend this supplement for its significant benefits.
Read More
9
Improves anxiety symptoms
9 people found this helpful
This is my repeat order after my initial trial. It's highly absorbable and free from chemical ingredients. Since B12 is beneficial for the nervous system, it has helped my chronic depression and anxiety disorders. My recent oxygen levels improved remarkably, and I’ve seen great progress in my neurological symptoms.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
- All Researches
9.5
Vitamin B12 supplementation benefits autoimmune patients
We explored the impact of vitamin B12 on patients with autoimmune disorders, particularly those experiencing symptoms often attributed to their underlying conditions. The study presented three cases of individuals with neuropathic pain, depression, fatigue, and muscle weakness, who had their symptoms initially misattributed to rheumatic diseases.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Read More
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Read More
9
We examined a fascinating case of a 54-year-old man experiencing the rare overlap of Guillain-Barré Syndrome (GBS) and autoimmune gastritis. After a thorough medical evaluation, which included MRI and biopsy, he was diagnosed with both GBS and a vitamin B12 deficiency linked to atrophic gastritis.
Treatment with intravenous immunoglobulin and methylcobalamin (vitamin B12) led to substantial improvement in his symptoms. This case highlights the importance of recognizing potential nutrient deficiencies, especially those impacting autoimmune disorders like GBS and autoimmune gastritis.
Treatment with intravenous immunoglobulin and methylcobalamin (vitamin B12) led to substantial improvement in his symptoms. This case highlights the importance of recognizing potential nutrient deficiencies, especially those impacting autoimmune disorders like GBS and autoimmune gastritis.
Read More
9
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
Read More
8
Vitamin B predicts GBS prognosis
We examined the levels of vitamin B and creatine kinase (CK-NAC) in 50 patients with Guillain-Barré Syndrome (GBS). Through clinical assessments, we compared the patients' functional abilities and found that a deficiency in vitamin B was linked to greater disease severity and respiratory complications.
However, while vitamin B levels seemed to offer insight into GBS prognosis, elevated CK-NAC levels did not show a significant correlation with disease severity. This points towards the importance of monitoring vitamin B as a potential prognostic tool in managing GBS.
However, while vitamin B levels seemed to offer insight into GBS prognosis, elevated CK-NAC levels did not show a significant correlation with disease severity. This points towards the importance of monitoring vitamin B as a potential prognostic tool in managing GBS.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 32 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Muscle relaxation benefits
21 people found this helpful
For nerve and muscle relaxation, this easily digestible form works excellently. I have been drinking it for over a year, experiencing reduced body aches and irritability. B12 helps relax muscle fibres, relieving tensions. My nails improved too; white spots indicated a lack of B12. I would have avoided many issues had I started this sooner; it truly impacts the nervous system positively.
Read More
9
Supports brain function
17 people found this helpful
As a vegan, I take this in monthly courses. It alleviates muscle and nervous tensions and enhances brain function. A deficiency in Vitamin B12 can lead to neurological disorders, even depression, especially in those over 40. I wholeheartedly recommend this supplement for its significant benefits.
Read More
9
Improves anxiety symptoms
9 people found this helpful
This is my repeat order after my initial trial. It's highly absorbable and free from chemical ingredients. Since B12 is beneficial for the nervous system, it has helped my chronic depression and anxiety disorders. My recent oxygen levels improved remarkably, and I’ve seen great progress in my neurological symptoms.
Read More
9
Improved emotional state
4 people found this helpful
Health to everyone, and I like it! As advised by my nutritionist, I took one capsule daily for a month. I noticed my emotional state improved, and I began responding calmly to stressful situations. I have sufficient energy for the day, my nervous system feels well, and I've been sleeping better. After testing, I found no deficiency in B12, so I've ordered it again for my mother to help with her autoimmune disorder.
Read More
9
No more shoulder stiffness
4 people found this helpful
I can't go a day without this! I've been taking it for peripheral nerve disorders and it's been effective. After 25 years of suffering from stiff shoulders, this has been the best choice for me. There are no side effects, and I feel great. I'm also taking E, and I rarely struggle now. The capsules are small enough to swallow easily, even for women with concerns about size.
Read More
Frequently Asked Questions
9
Improved emotional state
4 people found this helpful
Health to everyone, and I like it! As advised by my nutritionist, I took one capsule daily for a month. I noticed my emotional state improved, and I began responding calmly to stressful situations. I have sufficient energy for the day, my nervous system feels well, and I've been sleeping better. After testing, I found no deficiency in B12, so I've ordered it again for my mother to help with her autoimmune disorder.
7.5
Combats chronic fatigue
15 people found this helpful
I approached Vitamin B12 from Doctor's Best cautiously but felt its effects after three weeks. Chronic fatigue diminished, and my sleep improved. I will retest my blood levels, confident they’re better. This small capsule also appears beneficial for my immune system against coronavirus.
9
Energy boost experienced
3 people found this helpful
I wish you health! This chelated vitamin B12 is from a renowned brand that I trust. It’s the second time I’ve ordered it, and I’ve noticed an increase in energy and improvement in my nervous system, especially helping symptoms associated with my autoimmune disorder. I recommend combining it with DHA-500 for better memory and concentration.
9
Muscle relaxation benefits
21 people found this helpful
For nerve and muscle relaxation, this easily digestible form works excellently. I have been drinking it for over a year, experiencing reduced body aches and irritability. B12 helps relax muscle fibres, relieving tensions. My nails improved too; white spots indicated a lack of B12. I would have avoided many issues had I started this sooner; it truly impacts the nervous system positively.
9
Improves anxiety symptoms
9 people found this helpful
This is my repeat order after my initial trial. It's highly absorbable and free from chemical ingredients. Since B12 is beneficial for the nervous system, it has helped my chronic depression and anxiety disorders. My recent oxygen levels improved remarkably, and I’ve seen great progress in my neurological symptoms.
7.5
Increased productivity
35 people found this helpful
After taking two a day, I’ve noticed more energy and productivity. It also enhances my immune system, which is vital for my autoimmune disorder.
7.5
Significant neuralgia relief
6 people found this helpful
The effect on neuralgia is remarkable. After overcoming shingles, I've experienced lingering issues. I chose this brand for its purity. Since using it for over a month, the neuralgia has significantly improved, making a noticeable difference.
9
Reduced numbness
1 people found this helpful
I would describe B12 as essential. After my hands began to numb from hours at the computer, I started taking B12 upon advice. The numbness has lessened significantly, and my energy levels have increased.
9
Reduced back pain
2 people found this helpful
This is my favourite B12 for supporting my nervous system. I've been taking it for a year, with occasional breaks. It has calmed me down, improved my sleep, and relieved my lower back pain. This along with other B vitamins helps improve energy production, very beneficial for my autoimmune disorder.
7.5
Increased activity level
3 people found this helpful
My doctor recommended these vitamins, as they contain a therapeutic dose of 1500 mcg of B12. They are conveniently small and have no side effects. I’ve felt more vibrant and alert since I started taking them. I think they might help strengthen my immunity, which is particularly beneficial for my autoimmune disorder.
7.5
Metabolism improved
2 people found this helpful
I was advised by the hospital to take high doses of vitamin B due to an autoimmune disorder, which previously caused my tongue to swell. I’ve noticed improvements in my overall metabolism since starting this supplement. The capsule is small, which makes it easy to take.
6
Nerve regeneration support
2 people found this helpful
Vitamin B12 is crucial for nerve regeneration, especially for my autoimmune disorder, CIDP, which causes nerve damage. I've been using a high dosage for five years. I've also got my elderly mum the lower dosage to see if it helps with her sciatic pain.
8
Vitamin B predicts GBS prognosis
We examined the levels of vitamin B and creatine kinase (CK-NAC) in 50 patients with Guillain-Barré Syndrome (GBS). Through clinical assessments, we compared the patients' functional abilities and found that a deficiency in vitamin B was linked to greater disease severity and respiratory complications.
However, while vitamin B levels seemed to offer insight into GBS prognosis, elevated CK-NAC levels did not show a significant correlation with disease severity. This points towards the importance of monitoring vitamin B as a potential prognostic tool in managing GBS.
However, while vitamin B levels seemed to offer insight into GBS prognosis, elevated CK-NAC levels did not show a significant correlation with disease severity. This points towards the importance of monitoring vitamin B as a potential prognostic tool in managing GBS.
7
We explored a fascinating case of a 40-year-old woman suffering from long-standing, unclear symptoms, initially misdiagnosed with various conditions. After years of monitoring, her critically low vitamin B12 levels were finally recognized, revealing pernicious anemia as the root cause.
Thanks to treatment with B12 injections, we observed significant improvement in her neurological symptoms. This case illustrates the need for thorough evaluations in patients with non-specific symptoms, as addressing vitamin B12 deficiency can lead to meaningful improvements—even when classic signs are absent.
Thanks to treatment with B12 injections, we observed significant improvement in her neurological symptoms. This case illustrates the need for thorough evaluations in patients with non-specific symptoms, as addressing vitamin B12 deficiency can lead to meaningful improvements—even when classic signs are absent.
7
We explored the clinical characteristics of Chinese patients with autoimmune gastritis (AIG), focusing on how dietary and lifestyle factors influence its occurrence.
In a comprehensive case-control study involving 479 participants, we discovered that a diet rich in vitamin B12 may help protect against AIG. Interestingly, factors like cooking oil usage and autoimmune thyroid disease increased AIG risk.
Our findings suggest that what we eat and our lifestyle choices can significantly impact the development and prognosis of autoimmune gastritis.
In a comprehensive case-control study involving 479 participants, we discovered that a diet rich in vitamin B12 may help protect against AIG. Interestingly, factors like cooking oil usage and autoimmune thyroid disease increased AIG risk.
Our findings suggest that what we eat and our lifestyle choices can significantly impact the development and prognosis of autoimmune gastritis.
7
B12 and autoimmune conditions overview
We explored the intriguing relationship between vitamin B12 and autoimmune disorders through a case study involving a 64-year-old male with multiple autoimmune conditions. Our investigation revealed that this patient, who had a history of type 1 diabetes, was diagnosed with chronic autoimmune gastritis.
Upon further examination, we found he suffered from a deficiency in vitamin B12, which is often associated with autoimmune gastritis due to impaired absorption. Following this diagnosis, he commenced monthly vitamin B12 supplementation, which is a common treatment for individuals with similar conditions.
While vitamin B12 treatment addresses the deficiency, it's essential to acknowledge that its effects on autoimmune disorders as a standalone treatment remain unclear. This case illustrates the importance of monitoring vitamin levels in patients with autoimmune diseases but does not provide evidence suggesting significant benefits of B12 treatment on the autoimmune disorders themselves.
Ultimately, this emphasizes the need for continuous vigilance in identifying and addressing nutritional deficiencies, particularly in patients suffering from autoimmune conditions, even when specific symptoms may not be present.
Upon further examination, we found he suffered from a deficiency in vitamin B12, which is often associated with autoimmune gastritis due to impaired absorption. Following this diagnosis, he commenced monthly vitamin B12 supplementation, which is a common treatment for individuals with similar conditions.
While vitamin B12 treatment addresses the deficiency, it's essential to acknowledge that its effects on autoimmune disorders as a standalone treatment remain unclear. This case illustrates the importance of monitoring vitamin levels in patients with autoimmune diseases but does not provide evidence suggesting significant benefits of B12 treatment on the autoimmune disorders themselves.
Ultimately, this emphasizes the need for continuous vigilance in identifying and addressing nutritional deficiencies, particularly in patients suffering from autoimmune conditions, even when specific symptoms may not be present.
References
- Jatav VS, Sardana V, Bhushan B, Maheshwari D, Garg S, et al. Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure. J Assoc Physicians India. 2025;73:48. doi:10.59556/japi.73.0892
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- Ma XY, Hao Y, Xie YH, Cao Q, Sun DF, et al. Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China. J Gastroenterol Hepatol. 2025. doi:10.1111/jgh.16912
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Xiang H, Cai M. Coexistence of Guillain-Barré Syndrome and Subacute Combined Degeneration of the Spinal Cord Due to Autoimmune Gastritis: A Case Report and Literature Review. Cureus. 2024;16:e63084. doi:10.7759/cureus.63084
- Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, et al. Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Sci Transl Med. 2024;16:eadl3758. doi:10.1126/scitranslmed.adl3758
- Subtil J, Carvalho R, Rebelo AF, Subtil P. Autoimmune Polyglandular Syndrome Type 3: A Case Report. Cureus. 2024;16:e76152. doi:10.7759/cureus.76152
- Mansour M, Shamasnah A, Alsaadi D, Abu Saif S, Krama A. Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto's thyroiditis and pernicious anemia: a case report. J Med Case Rep. 2024;18:643. doi:10.1186/s13256-024-05002-3
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
- Fernandez I, Touzot F. Looking for ALPS: The value of a combined assessment of biochemical markers. Pediatr Allergy Immunol. 2024;35:e14135. doi:10.1111/pai.14135
- Yamada H, Toko M, Nakamori M, Ueno H, Aoki S, et al. Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging. J Neurovirol. 2024;30:197. doi:10.1007/s13365-024-01203-0
- Yang CW, Hsu HY, Lee YZ, Lee SJ. Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice. Biochem Biophys Res Commun. 2024;704:149668. doi:10.1016/j.bbrc.2024.149668
- Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. doi:10.1007/s00296-024-05539-y
